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Ionis and Spinout Strike $150M Deal With Novartis

Carlsbad-based Ionis Pharmaceuticals has landed yet another big payout.

Pharmaceutical giant Novartis will pay $150 million to license a cardiovascular drug from Ionis, it was announced Feb. 25. Ionis and its spinout Akcea Therapeutics will share the payment.

Novartis picked up the rights to Akcea-Apo(a)-LRx, a drug candidate intended for elevated levels of lipoprotein (a) that can’t be reduced by diet or exercise and that contribute to risks like blood clots. The large pharmaceutical will handle a phase 3 clinical study, and if the drug is approved, global commercialization.

Promising phase 2 clinical trial results laid the groundwork for the deal.

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“We believe that this therapy has the potential to be a significant advance for millions of people affected by cardiovascular disease around the world,” said Paula Soteropoulos, chief executive officer at Akcea.

The drug was discovered by Ionis and co-developed by Akcea and Ionis. The $150 million will go to Akcea, which will pay Ionis $75 million in common stock.

Ionis last year netted big deals, including Biogen paying the company $1 billion to develop neurological drugs.

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